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This finding related to combination therapy concurs with the study by Shankar and colleagues, which showed that patients who received combination therapy with a CTLA-4 inhibitor and PD-1/PD-L1 inhibitor had an increased risk for multisystem immune-related adverse events

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Using a patch-clamp experiment combined with single-neuron mRNA analysis, we verified that Glp1r + Ghsr + neurons were depolarized by GLP-1 and hyperpolarized by ghrelin